Pneumococcal 23 Immunization

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Schedule for vaccination using 23-valent polysaccharide vaccine (PPSV23) after 13-valent pneumococcal conjugate vaccine (PCV13) for children aged ≥2 years with underlying medical conditions:

 

1. Children who are immunocompromised, have sickle cell disease, or functional or anatomic asplenia.

2. Immunocompetent children with chronic illness.

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Key:

PPSV23 - 23-valent Pneumococcal Polysaccharide Vaccine 

PCV13 - 13-valent Pneumococcal Conjugate Vaccine

 

Pneumococcal Polysaccharide Vaccine 

• Purified pneumococcal polysaccharide (23 types)

• Not effective in children younger than 2 years 

• 60%–70% against invasive disease 

• Less effective in preventing pneumococcal pneumonia 

 

Pneumococcal Conjugate Vaccine 

• More than 90% effective against invasive disease caused by vaccine serotypes in children 

• 45% effective against vaccine-type non-bacteremic pneumococcal pneumonia in adults older than 65 years 

• 75% effective against vaccine- type invasive disease in adults older than 65 years 

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