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Pneumococcal 23 Immunization

Schedule for vaccination using 23-valent polysaccharide vaccine (PPSV23) after 13-valent pneumococcal conjugate vaccine (PCV13) for children aged ≥2 years with underlying medical conditions:


1. Children who are immunocompromised, have sickle cell disease, or functional or anatomic asplenia.

2. Immunocompetent children with chronic illness.


PPSV23 - 23-valent Pneumococcal Polysaccharide Vaccine 

PCV13 - 13-valent Pneumococcal Conjugate Vaccine


Pneumococcal Polysaccharide Vaccine 

  • Purified pneumococcal polysaccharide (23 types)

  • Not effective in children younger than 2 years 

  • 60%–70% against invasive disease 

  • Less effective in preventing pneumococcal pneumonia 


Pneumococcal Conjugate Vaccine 

  • More than 90% effective against invasive disease caused by vaccine serotypes in children 

  • 45% effective against vaccine-type non-bacteremic pneumococcal pneumonia in adults older than 65 years 

  • 75% effective against vaccine- type invasive disease in adults older than 65 years 

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